We have reports from customers who are using 3ds Max 2013 and Qube, they are unable to render on their 48-core hosts.
It's not restricted to just Qube jobs. Starting Max interactively when logged into the worker and attempting to render a sphere will crash Max.
The only version that was tested was 3ds Max 2013.
From an Autodesk forum posting: http://forums.autodesk.com/t5/Installation-Hardware-OS/Scanline-render-on-48cores/td-p/4666169